HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
L-(-)-Xylose
XYLOSE · L-(-)-XYLOSE · L-XYL · (2S,3R,4S)-2,3,4,5-Tetrahydroxypentanal · XYLOSE, L · aldehydo-L-xylose · L-XYLOSE · L-Xylose,99%
Identifikatoren & physikalische Daten
| CAS No. | 609-06-3 |
|---|---|
| Summenformel | C5H10O5 |
| Durchschnittliche Molmasse | 150,13 g/mol |
| Monoisotopische Masse | 150,05282342 g/mol |
| SMILES | O=C[C@@H](O)[C@H](O)[C@@H](O)CO |
| InChIKey | PYMYPHUHKUWMLA-WISUUJSJSA-N |
| PubChem CID | 95259 |
| ChEBI | CHEBI:17979 |
| EC No. | 210-174-1 |
| DTXSID | DTXSID50883340 |
| Lokaler Name | L-(-)-Xylose |
Chemische & physikalische Eigenschaften
| XLogP | -2,3 |
|---|---|
| Polarare Oberfläche (TPSA) | 98 |
| H-Brücken-Donoren | 4 |
| H-Brücken-Akzeptoren | 5 |
| Frei drehbare Bindungen | 4 |
| Schwere Atome | 10 |
| Formalladung | 0 |
| Komplexität | 104 |
| Schmelzpunkt | 150-152 °C(lit.) |
| Siedepunkt | 191.65°C (rough estimate) |
| Dichte | 1.525 |
| Brechungsindex | -20 ° (C=10, H2O) |
| Lagerbedingungen | Keep in dark place,Sealed in dry,Room Temperature |
| Löslichkeit | H2O: 0.1 g/mL, clear, colorlesswithin almost transparency |
| Aggregatzustand | Crystalline Powder |
| pKa (Säurekonstante) | 12.46±0.20(Predicted) |
| Farbe | White to off-white |
| BRN | 1723080 |
| InChI | 1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m1/s1 |
| InChIKey | SRBFZHDQGSBBOR-VVZXFQNISA-N |
| SMILES | O[C@H]1COC(O)[C@@H](O)[C@@H]1O |
| LogP (Verteilungskoeffizient) | -2.390 (est) |
| CAS Datenbank | 609-06-3(CAS DataBase Reference) |
| EPA chemische Informationen | L-Xylose (609-06-3) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 71.4% (5 of 7) of all reports.WarningH315 (28.6%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 7 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | L-Xylose: Does not have an individual approval but may be used under an appropriate group standard |
| Hazard Classes and Categories | Skin Irrit. 2 (28.6%) |
| F | 3-10 |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 29400000 |
| R-Sätze (R) | 36/37/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 24/25-36-26 |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Verwenden
L-Xylose is used in the synthesis of L-Xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Herstellung & Synthese
synthetische
L-Xylose can be produced from L-xylulose by isomerization. This can be achieved either enzymatically or chemically under alkaline conditions. The equilibrium of the reaction between D-xylose and D-xylulose in an aqueous solution has been determined at pH 6.8-7.4 and at 25 °C to be 85:15 in favor of D-xylose (Tewari et al., 1985).