Ceftiofur Hydrochloride

HCID 9937686CAS 103980-44-5

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Grundinformationen

Standard-SMILES: CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSC(=O)c3ccco3)CS[C@H]12)c1csc(N)n1.Cl
InChIKey: KEQFDTJEEQKVLM-JUODUXDSSA-N
Summenformel: C19H18ClN5O7S3
Durchschnittliche Molmasse: 560 g/mol
Monoisotopische Masse: 559,0056886

Überblick

Ceftiofur Hydrochloride is the hydrochloride salt form of ceftiofur, a semisynthetic, beta-lactamase-stable, broad-spectrum, third-generation cephalosporin with antibacterial activity. Ceftiofur binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Namen und Bezeichner

Bevorzugter Name: Ceftiofur Hydrochloride
IUPAC: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(furan-2-carbonylsulfanylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrochloride

Namen und Synonyme

Ceftiofur hydrochloride103980-44-5Ceftiofur HClExcenelCeftiofur monohydrochlorideU-64279ANSC-759845DTXSID1010343006822A07436SpectramastSpectramast DCSpectramast LC

Weitere Namen anzeigen

Cefenil RTUEXCENEL RTU EZRefChem:54738Spectramast DC Sterile SuspensionSpectramast LC Sterile SuspensionDTXCID201518941Excenel Sterile Suspension, Excenel RTU, Excenel Sterile PowderMFCD04038020

Datenbank-Bezeichner

CAS: 103980-44-5
PubChem CID: 9937686
DTXSID: DTXSID101034300
ChEMBL: CHEMBL2106486
UNII: 6822A07436
EC Number: 600-507-2

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 256 Å²
H-Brücken-Donoren: 4
H-Brücken-Akzeptoren: 13
Frei drehbare Bindungen: 9
Schwere Atome: 35
Formalladung: 0
Komplexität: 945

Experimentelle und physikochemische Eigenschaften

Animal DrugsActive Ingredients (Ceftiofur Hydrochloride) -> FDA Greenbook

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

This chemical does not meet GHS hazard criteria for 1.1% (1 of 90) of reports.

Danger

H317 (60%): May cause an allergic skin reaction [Warning Sensitization, Skin]

P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P319, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 90 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.