Hydrochloric Acid → Ceftiofur Hydrochloride

HRID 863649

Reaktionsgleichung

Reaktionsgleichung von HRID 863649
[ClH:1].[CH3:2][O:3]/[N:4]=[C:5](\[C:12]([NH:14][C@@H:15]1[C:18](=[O:19])[N:17]2[C:20]([C:33]([OH:35])=[O:34])=[C:21]([CH2:24][S:25][C:26]([C:28]3[O:32][CH:31]=[CH:30][CH:29]=3)=[O:27])[CH2:22][S:23][C@H:16]12)=[O:13])/[C:6]1[N:10]=[C:9]([NH2:11])[S:8][CH:7]=1>O.CC(C)=O>[CH3:2][O:3]/[N:4]=[C:5](\[C:12]([NH:14][C@@H:15]1[C:18](=[O:19])[N:17]2[C:20]([C:33]([OH:35])=[O:34])=[C:21]([CH2:24][S:25][C:26]([C:28]3[O:32][CH:31]=[CH:30][CH:29]=3)=[O:27])[CH2:22][S:23][C@H:16]12)=[O:13])/[C:6]1[N:10]=[C:9]([NH2:11])[S:8][CH:7]=1.[ClH:1]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 6328657Ceftiofur

Produkt 1

HCID 9937686Ceftiofur Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 18366337Propan-2-one--water (1/1)Lösungsmittel

Versuchsvorschrift

The preparation of crystalline ceftiofur hydrochloride is considered to involve a typical crystallization. Several methods for the preparation of ceftiofur hydrochloride are described in U.S. Pat. No. 4,902,683. In one readily used method, once the hydrochloride salt is obtained by adding hydrochloric acid to a water/acetone solution of ceftiofur, the resulting solution is cooled slowly to obtain crystalline ceftiofur hydrochloride.

Aufarbeitung

  1. temperaturethe resulting solution is cooled slowly

Quellen und Nachweise

ORD-Eintrag
ord-c8c261744d074e3ca4caa76f3e176479
Quelldatensatz
uspto-grants-1998_02
Patentnummer
US05721359

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