Hydrogen Bromide → 5-Iodobenzene-1,3-diol

HRID 1003945

Reaktionsgleichung

Reaktionsgleichung von HRID 1003945
C[O:2][C:3]1[CH:4]=[C:5]([I:11])[CH:6]=[C:7]([O:9]C)[CH:8]=1.Br>C(O)(=O)C>[OH:2][C:3]1[CH:4]=[C:5]([I:11])[CH:6]=[C:7]([OH:9])[CH:8]=1

Komponenten

4

Edukt 2

HCID 260Hydrogen BromideHCID 6401791-Iodo-3,5-dimethoxybenzene

Produkt 1

HCID 6167555-Iodobenzene-1,3-diolAusbeute 99,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

3,5-Dimethoxyiodobenzene (1.19 g) is dissolved in acetic acid (10 ml), and thereto is added 47% hydrobromic acid (10 ml) at room temperature, and the mixture is refluxed for 15 hours. The reaction mixture is cooled to room temperature, and concentrated to dryness under reduced pressure. The residue is dissolved in ethyl acetate, and the organic layer is washed with water, dried, and concentrated under reduced pressure to give 3,5-dihydroxyiodobenzene (1.06 g).

Aufarbeitung

  1. temperaturethe mixture is refluxed for 15 hours
  2. concentrationconcentrated to dryness under reduced pressure
  3. dissolutionThe residue is dissolved in ethyl acetate
  4. washthe organic layer is washed with water
  5. customdried
  6. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-82fa8e9a43cd431faf20c55195195adb
Quelldatensatz
uspto-grants-2000_04
Patentnummer
US06048842

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