Acetyl chloride → N-Methyl-phenylglycine methyl ester hydrochloride

HRID 1003960

Reaktionsgleichung

Reaktionsgleichung von HRID 1003960
[CH3:1][N:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:3][C:4]([OH:6])=[O:5].[C:13]([Cl:16])(=O)C>CO>[ClH:16].[CH3:13][O:5][C:4](=[O:6])[CH2:3][N:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:1]

Komponenten

4

Edukt 2

HCID 6367Acetyl chlorideHCID 420843N-Methyl-N-phenyl-glycine

Produkt 1

HCID 70291077N-Methyl-phenylglycine methyl ester hydrochlorideAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Prepared by Method A of Example 19 but using N-methyl-phenylglycine (prepared in turn from 2-chlorophenylacetic acid and methylamine) (3.5 g) methanol (20 ml) and acetyl chloride (40 ml) over 48 hours. The title compound was obtained in 94% yield, after trituration with methanol, as a white solid.

Aufarbeitung

  1. customPrepared by Method A of Example 19
  2. customover 48 hours

Quellen und Nachweise

ORD-Eintrag
ord-3f0ae84401de4753b2d31985f3ef5bd9
Quelldatensatz
uspto-grants-2000_04
Patentnummer
US06048852

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