Hydrochloric Acid → 4-Cyclopentylbutanal

Methoxymethyl triphenylphosphonium chloride (36 g, 0.11 mol) was suspended in anhydrous tetrahydrofuran (400 mL) and treated with potassium tert-butoxide (12.8 g, 0.11 mol). The reaction stirred for 10 minutes and 3-cyclopentyl-propionaldehyde (10.29 g, 0.082 mol, Example 76) was added dropwise as a solution in anhydrous tetrahydrofuran (100 mL). After 24 hours the reaction was quenched with water. The reaction was diluted with diethyl ether (600 mL) and washed with water (3×300 mL). The organic phase was dried (MgSO4) and concentrated to afford an oil. The oil was taken up in tetrahydrofuran (50 mL) and concentrated hydrochloric acid (20 mL) was added. After six hours, the reaction was diluted with diethyl ether and washed with water (2×200 mL). The organic phase was dried (MgSO4), filtered, and concentrated to yield an oil. The oil was filtered through a pad of silica gel to yield 4-cyclopentyl-butyraldehyde as an oil (6.21 g, 54%).

1. customAfter 24 hours the reaction was quenched with water
2. additionThe reaction was diluted with diethyl ether (600 mL)
3. washwashed with water (3×300 mL)
4. dry with materialThe organic phase was dried (MgSO4)
5. concentrationconcentrated
6. customto afford an oil
7. waitAfter six hours
8. washwashed with water (2×200 mL)
9. dry with materialThe organic phase was dried (MgSO4)
10. filtrationfiltered
11. concentrationconcentrated
12. customto yield an oil
13. filtrationThe oil was filtered through a pad of silica gel

ORD-Eintrag

ord-69a7c5587f97418fa54d32fb6df62a6f

Quelldatensatz

uspto-grants-2000_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06051586