Triethylamine → 3-(4-Chlorophenyl)-1-methyl-4,5-di(trifluoromethyl)-1H-pyrazole

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

5.7 g (41 nmol) of gaseous hexafluoro-2-butyne were passed at below (-50)° C. into a suspension, cooled to (-70)° C., of 9 g (36 mmol) of α-bromo-4-chlorobenzaldehyde methylhydrazone in 100 ml of toluene. The mixture was subsequently heated to (-25)° C., and 8.4 g (83 mmol) of triethylamine were added dropwise at this temperature. After the mixture had been stirred for 2 hours at this temperature and for a further 16 hours at approx. 20° C., it as washed with water, dried over magnesium sulfate and finally concentrated.

Herkunft & Nachweise