Water → HCID 22674439, Verbindung

Reaktionsgleichung

[NH2:1][CH2:2][CH2:3][NH:4][C:5]1[N:6]=[C:7]([C:14]([C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)=[O:15])[C:8]2[S:13][CH:12]=[CH:11][C:9]=2[N:10]=1.[OH2:21].[CH3:22][N:23]([CH:25]=[O:26])C>>[S:17]1[CH:18]=[CH:19][CH:20]=[C:16]1[C:14]([C:7]1[C:8]2[S:13][CH:12]=[CH:11][C:9]=2[N:10]=[C:5]([NH:4][CH2:3][CH2:22][NH:23][C:25]([NH:1][CH2:2][CH2:3][NH:4][C:5]2[N:6]=[C:7]([C:14]([C:16]3[S:17][CH:18]=[CH:19][CH:20]=3)=[O:15])[C:8]3[S:13][CH:12]=[CH:11][C:9]=3[N:10]=2)=[O:26])[N:6]=1)=[O:21]

Komponenten

Edukt 3

HCID 962Water

HCID 6228Dimethylformamide

HCID 226743752-(2-Aminoethylamino)thieno[3,2-d]pyrimidin-4-yl 2-thienylmethanone2×

Produkt 1

HCID 22674439HCID 22674439, VerbindungAusbeute 31 %

Versuchsvorschrift

A solution of 2-(2-aminoethylamino)thieno[3,2-d]pyrimidin-4-yl 2-thienylmethanone (0.10 g, 0.33 mmol) in anhydrous DMF (4 mL) under argon was treated with 1,1-carbonyldiimidazole (0.05 g, 0.33 mmol), stirred for 2 h, treated with 2-(2-aminoethylamino)thieno[3,2-d]pyrimidin-4-yl 2-thienylmethanone (0.10 g, 0.33 mmol), stirred at room temperature for 4 h and then at 60° C. for 16 h, cooled, poured into water (25 mL) and the resulting orange suspension filtered and dried in vacuo to give the title compound (0.13 g, 31%) as an orange solid.