Iodoethane → 4-(2-Bromo-5-ethoxybenzyl)-1-[(2-chlorophenyl)acetyl]piperidine

Temperatur

60 °C

Iodoethane (311.9 mg, 2.000 mmol) and potassium carbonate (500.0 mg, 3.619 mmol) were added to a solution (3 ml) of 4-(2-bromo-5-hydroxybenzyl)-1-[(2-chlorophenyl)-acetyl]piperidine (400.0 mg, 0.952 mmol) in N,N-dimethylformamide, and the resulting mixture was stirred at 60° C. for 3 hours. The reaction was terminated by adding water (20 ml), followed by extraction with diethyl ether. The extract layer was washed with an aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then distilled under reduced pressure to remove the solvent, whereby the title compound (426.7 mg, 0.952 mmol) was quantitatively obtained.

1. customThe reaction was terminated
2. additionby adding water (20 ml)
3. extractionfollowed by extraction with diethyl ether
4. washThe extract layer was washed with an aqueous sodium chloride solution
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationdistilled under reduced pressure

ORD-Eintrag

ord-ec5ac8c072cc4487a5aa1914551c65a0

Quelldatensatz

uspto-grants-2004_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06787560B2