Water → HCID 22672646, Verbindung

HRID 1006673Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1006673
C[O:2][C:3]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:4]=1[CH2:5][NH:6][C:7]1[C:8]2[N:9]([C:13]([CH3:17])=[C:14]([CH3:16])[N:15]=2)[CH:10]=[CH:11][CH:12]=1.B(Br)(Br)Br.O>C(Cl)Cl>[OH:2][C:3]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:4]=1[CH2:5][NH:6][C:7]1[C:8]2[N:9]([C:13]([CH3:17])=[C:14]([CH3:16])[N:15]=2)[CH:10]=[CH:11][CH:12]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 25134Boron tribromideHCID 22672579HCID 22672579, Verbindung

Produkt 1

HCID 22672646HCID 22672646, VerbindungAusbeute 57 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel3×

Reaktionsbedingungen

Temperatur
-73 °C

Versuchsvorschrift

8-(2-methoxy-6-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridine (0.14 g, 0.48 mmol) was solved in methylene chloride (9 ml) and the mixture was cooled to −73° C. Boron tribromide in methylene chloride (1M) (2.37 ml, 2.37 mmol) was added dropwise and the mixture was stirred for 20 h. in a nitrogen atmosphere and the temperature was allowed to raise to room temperature. The reaction mixture was cooled on ice and ice, water and methylene chloride were added. The organic layer was separated, washed with saturated sodium bicarbonate, dried and evaporated under reduced pressure to give 0.077 g (57%) of the title compound

Aufarbeitung

  1. temperatureto raise to room temperature
  2. additionwere added
  3. customThe organic layer was separated
  4. washwashed with saturated sodium bicarbonate
  5. customdried
  6. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a00155eca5e24e6f985f0bfeee20a1c7
Quelldatensatz
uspto-grants-2004_09
Patentnummer
US06790960B2

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