Hydrazine hydrate (1:1) → 2-Fluoro-6-hydrazinylpyridine

HRID 1007559Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1007559
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](F)[N:3]=1.O.[NH2:10][NH2:11]>C(O)(C)C>[F:1][C:2]1[N:3]=[C:4]([NH:10][NH2:11])[CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 739342,6-Difluoropyridine

Produkt 1

HCID 14753322-Fluoro-6-hydrazinylpyridineAusbeute 76,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

2,6-Difluoropyridine (25 g), isopropyl alcohol (100 ml) and hydrazine hydrate (40 ml) were mixed and refluxed with heating for 3 hours. The isopropyl alcohol was evaporated under reduced pressure, and the residue was added with water. The deposited crystals were collected by filtration, washed with water and dried to obtain 6-fluoro-2-hydrazinopyridine (21.2 g, yield: 76.8%). Coloration was observed during drying, and accordingly, the product was used for the next reaction immediately after the drying.

Aufarbeitung

  1. temperaturerefluxed
  2. temperaturewith heating for 3 hours
  3. customThe isopropyl alcohol was evaporated under reduced pressure
  4. additionthe residue was added with water
  5. filtrationThe deposited crystals were collected by filtration
  6. washwashed with water
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-22c6055c015242ca8bf909fdea1112ea
Quelldatensatz
uspto-grants-2004_09
Patentnummer
US06794509B1

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