Ammonium Hydroxide → (S)-5-Hydroxytryptophan amide

Reaktionsgleichung

Cl.CO[C:4](=[O:18])[C@H:5]([CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[NH:10][CH:9]=1)[NH2:6].[OH-].[NH4+:20]>>[OH:17][C:14]1[CH:15]=[C:16]2[C:11]([NH:10][CH:9]=[C:8]2[CH2:7][C@@H:5]([C:4]([NH2:20])=[O:18])[NH2:6])=[CH:12][CH:13]=1

Komponenten

Edukt 2

HCID 14923Ammonium Hydroxide

HCID 24802218methyl (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoate hydrochloride

Produkt 1

HCID 9899303(S)-5-Hydroxytryptophan amide

Versuchsvorschrift

(S)-5-Hydroxytryptophan methyl ester hydrochloride (0.247 g, 0.91 mmol) was stirred overnight at room temperature in ammonium hydroxide (10 mL). After removal of volatiles under vacuum, the title compound of example 44 was obtained as a dark solid.

Aufarbeitung

customAfter removal of volatiles under vacuum

Quellen und Nachweise

ORD-Eintrag: ord-e1014672ce81403e92305650bdc5495f
Quelldatensatz: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06794404B2

Notizen zur Reaktion

Wird geladen…