Iodoethane → ethyl 2-(5-methyl-1H-tetrazol-1-yl)nicotinate

HRID 1007769Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1007769
[CH3:1][C:2]1[N:6]([C:7]2[N:15]=[CH:14][CH:13]=[CH:12][C:8]=2[C:9]([OH:11])=[O:10])[N:5]=[N:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:22](I)[CH3:23]>CC(C)=O>[CH3:1][C:2]1[N:6]([C:7]2[N:15]=[CH:14][CH:13]=[CH:12][C:8]=2[C:9]([O:11][CH2:22][CH3:23])=[O:10])[N:5]=[N:4][N:3]=1

Komponenten

5

Edukt 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 121328602-(5-Methyl-1H-tetrazol-1-yl)nicotinic acid

Produkt 1

HCID 12132861ethyl 2-(5-methyl-1H-tetrazol-1-yl)nicotinate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

2-(5-Methyl-1H-tetrazol-1-yl)nicotinic acid (5.6 g, 27 mmole) was suspended in acetone (250 mL), potassium carbonate (5 g) and ethyl iodide (5 mL) were added and the reaction mixture was heated at reflux for 2 hours. The acetone was removed under vacuum. The residue was partitioned between water and dichloromethane. The dichloromethane layer was separated, dried, then concentrated under vacuum to provide 6.3 g of ethyl 2-(5-methyl-1H-tetrazol-1-yl)nicotinate.

Aufarbeitung

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux for 2 hours
  3. customThe acetone was removed under vacuum
  4. customThe residue was partitioned between water and dichloromethane
  5. customThe dichloromethane layer was separated
  6. customdried
  7. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-9779f5845f3c41919d31540df367e37e
Quelldatensatz
uspto-grants-2004_09
Patentnummer
US06797716B2

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