Sodium Methoxide → HCID 59908492, Verbindung
Reaktionsgleichung
[CH2:1]([C@@H:5]([C:20]([N:22]1[CH2:26][CH2:25][CH2:24][C@H:23]1[C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])=[O:21])[C@@H:6]([O:11]C(=O)C1C=CC=CC=1)[C:7]([O:9][CH3:10])=[O:8])[CH2:2][CH2:3][CH3:4].C[O-].[Na+]>CO>[CH2:1]([C@@H:5]([C:20]([N:22]1[CH2:26][CH2:25][CH2:24][C@H:23]1[C:27]([O:29][C:30]([CH3:31])([CH3:33])[CH3:32])=[O:28])=[O:21])[C@@H:6]([OH:11])[C:7]([O:9][CH3:10])=[O:8])[CH2:2][CH2:3][CH3:4]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To methyl 3-(R)-n-butyl-3-[2-(S)-tert-butoxycarbonylpyrrolidin-1-ylcarbonyl)-2-(R)-benzoyloxypropionate H-2 (8.7 mmol) in methanol (25 mL) at 0° C. was added sodium methoxide (catalytic; pH adjusted to 10) and the solution stirred for 2 h. Amberlite IR-120 resin (H+ form) was added, then the solution was filtered and concentrated to afford methyl 3-(R)-n-butyl-3-[2-(S)-tert-butoxycarbonylpyrrolidin-1-yl-carbonyl)-2-(R)-hydroxypropionate H-3 (quant.).