Reaktionsgleichung
[Cl:1][C:2]1[CH:8]=[C:7]([O:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=3)[N:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][C:3]=1[NH2:4].ClC(Cl)(O[C:28](=[O:34])OC(Cl)(Cl)Cl)Cl.[NH2:36][C:37]1[N:42]=[C:41]([CH3:43])[C:40]([Br:44])=[CH:39][CH:38]=1.CO>C(Cl)(Cl)Cl.C(N(CC)CC)C.ClCCl>[Br:44][C:40]1[CH:39]=[CH:38][C:37]([NH:36][C:28]([NH:4][C:3]2[CH:5]=[CH:6][C:7]([O:9][C:10]3[C:19]4[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=4)[N:13]=[CH:12][CH:11]=3)=[CH:8][C:2]=2[Cl:1])=[O:34])=[N:42][C:41]=1[CH3:43]Komponenten
8
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline (122 mg) was dissolved in chloroform (10 ml) and triethylamine (1 ml), and a solution of triphosgene (110 mg) in dichloromethane was then added to the solution. The mixture was stirred at room temperature for 30 min. Next, 6-amino-3-bromo-2-methylpyridine (208 mg) was added to the reaction solution, and the mixture was stirred at room temperature for 2 hr. Methanol was added to the reaction solution, and the solvent was removed by distillation under the reduced pressure. The residue was purified by chromatography on silica gel by development with chloroform/acetone (2/1) to give 155 mg (yield 77%) of the title compound.
Aufarbeitung
- stirringthe mixture was stirred at room temperature for 2 hr
- customthe solvent was removed by distillation under the reduced pressure
- customThe residue was purified by chromatography on silica gel by development with chloroform/acetone (2/1)
Quellen und Nachweise
- ORD-Eintrag
- ord-363cde1534944849b2c41718f960045c
- Quelldatensatz
- uspto-grants-2004_09
- Patentnummer
- US06797823B1
Verknüpfte Notizen
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