Methyl acetoacetate → HCID 10352731, Verbindung

8.5 g (0.05 mol) of 2-hydrazino benzonitrile hydrochloride, 6 g (0.05 mol) of methyl acetoacetate and 100 ml of methanol were added into a 250 ml reaction flask, and then 50% methanol sodium solution (5.5 g (0.051 mol) sodium methoxide dissolved in 50 ml methanol) was added under stirring. After stirring for 10 min, the mixture was heated and refluxed for 6 h, and immediately filtered. The solid was washed with 20 ml of methanol. The methanol was recovered until the remained volume was 50 ml. 200 ml of ice water was poured with stirring to give the solid. The solid was filtered and washed with water to give 7 g of light yellow solid.

1. stirringAfter stirring for 10 min
2. temperaturethe mixture was heated
3. temperaturerefluxed for 6 h
4. filtrationimmediately filtered
5. washThe solid was washed with 20 ml of methanol
6. customThe methanol was recovered until the remained volume
7. addition200 ml of ice water was poured
8. stirringwith stirring
9. customto give the solid
10. filtrationThe solid was filtered
11. washwashed with water

ORD-Eintrag

ord-04bcc27f5bf042dc9157d034a50db635

Quelldatensatz

uspto-grants-2011_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07973036B2