Bromine → 5-Bromo-4-ethylthiazol-2-amine

HRID 1009024Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1009024
[CH2:1]([C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1)[CH3:2].[Br:9]Br>S(=O)(=O)(O)O>[Br:9][C:7]1[S:6][C:5]([NH2:8])=[N:4][C:3]=1[CH2:1][CH3:2]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 123782054-Ethyl-1,3-thiazol-2-amine

Produkt 1

HCID 665201935-Bromo-4-ethylthiazol-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

The above prepared 4-ethyl-thiazol-2-ylamine (1.125 g, 8.77 mmol) was dissolved in 4.5 mL of 20% aq. sulfuric acid, cooled to 0° C., and treated with Br2 (0.494 mL, 1.1 eq.). After 10 Min., the reaction mixture was carefully poured onto crashed ice/Na2CO3, twofold extracted with ethyl acetate, washed with water, dried over sodium sulfate, and evaporated to dryness. Thereby, 1.306 g of the title compound was obtained as light brown viscous oil, sufficiently pure to be used for the next step.

Aufarbeitung

  1. addition, the reaction mixture was carefully poured
  2. extractiontwofold extracted with ethyl acetate
  3. washwashed with water
  4. dry with materialdried over sodium sulfate
  5. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-fa9f99eb0d5942bb87242111f3aa8147
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07973051B2

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