Tert-butyl (5-ethynyl-4-methylthiazol-2-yl)carbamate → HCID 86630952, Verbindung

HRID 1009034Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1009034
[C:1]([O:5][C:6](=[O:16])[NH:7][C:8]1[S:9][C:10]([C:14]#[CH:15])=[C:11]([CH3:13])[N:12]=1)([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[C:1]([O:5][C:6](=[O:16])[NH:7][C:8]1[S:9][C:10]([CH2:14][CH3:15])=[C:11]([CH3:13])[N:12]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 86630951Tert-butyl (5-ethynyl-4-methylthiazol-2-yl)carbamate

Produkt 1

HCID 86630952HCID 86630952, VerbindungAusbeute 92,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

The above prepared (5-ethynyl-4-methyl-thiazol-2-yl)-carbamic acid tert-butyl ester (0.420 g, 1.76 mmol) was dissolved in 12 mL of ethyl acetate and hydrogenated over 0.200 g of Pd on charcoal (10%) at atmospheric pressure and ambient temperature over night. Filtration over a pad of Celite and evaporation off all solvents yielded 0.396 g of the title product as light brown viscous oil, sufficiently pure for the next step.

Aufarbeitung

  1. filtrationFiltration
  2. customover a pad of Celite and evaporation off all solvents

Quellen und Nachweise

ORD-Eintrag
ord-81f38227d37f4ede8ea8309cfe12dee0
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07973051B2

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