5-Ethynyl-4-phenyl-thiazol-2-ylamine → 2-Thiazolamine, 5-ethyl-4-phenyl-

HRID 1009047Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1009047
[C:1]([C:3]1[S:7][C:6]([NH2:8])=[N:5][C:4]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)#[CH:2]>C(OCC)(=O)C.[Pd]>[CH2:1]([C:3]1[S:7][C:6]([NH2:8])=[N:5][C:4]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:2]

Komponenten

4

Edukt 1

HCID 866309595-Ethynyl-4-phenyl-thiazol-2-ylamine

Produkt 1

HCID 1475602-Thiazolamine, 5-ethyl-4-phenyl-Ausbeute 74,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

The above prepared 5-ethynyl-4-phenyl-thiazol-2-ylamine (0.665 g, 3.321 mmol) was dissolved in 12 mL of ethyl acetate and hydrogenated over 0.330 g of Pd on charcoal (10%) at atmospheric pressure and ambient temperature over night. Filtration over a pad of Celite and evaporation off all solvents, followed by flash chromatography (SiO2, hexane/ethyl acetate=65/35), yielded 0.505 g of the title product as yellow viscous oil.

Aufarbeitung

  1. filtrationFiltration
  2. customover a pad of Celite and evaporation off all solvents

Quellen und Nachweise

ORD-Eintrag
ord-368be31b240c4e19958fc79b921b7f23
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07973051B2

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