Sodium methanethiolate → 4-Methyl-5-(methylsulfanyl)-1,3-thiazol-2-amine
Reaktionsgleichung
Br[C:2]1[S:6][C:5]([NH2:7])=[N:4][C:3]=1[CH3:8].[CH3:9][S-:10].[Na+]>CO>[CH3:8][C:3]1[N:4]=[C:5]([NH2:7])[S:6][C:2]=1[S:10][CH3:9]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
5-Bromo-4-methyl-thiazol-2-ylamine (1.35 g, 7 mmol,) was dissolved in methanol abs. (13.5mL) and sodium methanethiolate (0.6 g, 7.7 mmol) 1.1 equiv.) was added portionwise at rt. After stirring overnight, the dark colored mixture was concentrated under reduced pressure and purified over a 50 g silica cartridge (NH2-modified) with ethyl acetate as eluent. The desired fractions were evaporated to give the title compound as a light yellow solid: 180 mg, MS (ISP): m/e 161.1 (M+H)+
Aufarbeitung
- concentrationthe dark colored mixture was concentrated under reduced pressure
- custompurified over a 50 g silica cartridge (NH2-modified) with ethyl acetate as eluent
- customThe desired fractions were evaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-99a3bb1bee3d470295e3d3edce32c9b4
- Quelldatensatz
- uspto-grants-2011_07
- Patentnummer
- US07973051B2
Notizen zur Reaktion
Wird geladen…