Hydrochloric Acid → HCID 25111160, Verbindung

HRID 1009746Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1009746
[CH2:1]([N:3]1[CH:7]=[C:6]([NH:8][C:9](=[O:34])[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]3[C:27]4[C:22](=[CH:23][C:24]([O:32][CH3:33])=[C:25]([C:28]([O:30]C)=[O:29])[CH:26]=4)[N:21]=[CH:20][CH:19]=3)=[CH:13][CH:12]=2)[CH:5]=[N:4]1)[CH3:2].[OH-].[Li+].Cl>CO>[CH2:1]([N:3]1[CH:7]=[C:6]([NH:8][C:9](=[O:34])[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]3[C:27]4[C:22](=[CH:23][C:24]([O:32][CH3:33])=[C:25]([C:28]([OH:30])=[O:29])[CH:26]=4)[N:21]=[CH:20][CH:19]=3)=[CH:13][CH:12]=2)[CH:5]=[N:4]1)[CH3:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 25112108N-(1-ethylpyrazol-4-yl)-2-[4-(7-methoxy-6-methoxycarbonylquinolin-4-yloxy)phenyl]acetamide

Produkt 1

HCID 25111160HCID 25111160, VerbindungAusbeute 57,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of N-(1-ethylpyrazol-4-yl)-2-[4-(7-methoxy-6-methoxycarbonylquinolin-4-yloxy)phenyl]acetamide (0.05 g), lithium hydroxide (0.01 g) and methanol (1 ml) was stirred at ambient temperature for 14 hours. The resultant mixture was acidified to pH2 by the addition of 2N aqueous hydrochloric acid. The precipitate was isolated, washed with water and with diethyl ether and dried under vacuum. There was thus obtained the title compound (0.028 g); 1H NMR: (DMSOd6) 1.32 (t, 3H), 3.63 (s, 2H), 3.97 (s, 3H), 4.03-4.11 (m, 2H), 6.48 (d, 1H), 7.27 (d, 2H), 7.42 (s, 1H), 7.46 (d, 2H), 7.5 (s, 1H), 7.9 (s, 1H), 8.54 (s, 1H), 6.67 (d, 1H), 10.21 (s, 1H); Mass Spectrum: M+H+ 447.

Aufarbeitung

  1. customThe precipitate was isolated
  2. washwashed with water and with diethyl ether
  3. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-b7a84ee4b7454b7a86c402f4ee2c9ecb
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07973164B2

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