Sodium Hydroxide → 4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine

HRID 1010

Reaktionsgleichung

Reaktionsgleichung von HRID 1010
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[C:3]=1[O:9][CH3:10].[C:11]([C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1)([CH3:14])([CH3:13])[CH3:12].[OH-].[Na+]>C1(O)C=CC=CC=1>[C:11]([C:15]1[CH:16]=[CH:17][C:18]([NH:19][C:2]2[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[C:3]=2[O:9][CH3:10])=[CH:20][CH:21]=1)([CH3:14])([CH3:12])[CH3:13]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 698614-Tert-ButylanilineHCID 105830464-Chloro-3-methoxy-2-methylpyridine

Produkt 1

HCID 196939534-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 996PhenolLösungsmittel

Versuchsvorschrift

7.9 g of 4-chloro-3-methoxy-2-methylpyridine and 22.4 g of 4-tert-butylaniline are heated at 120° C. for 8 hours in 20 g of phenol. After cooling, the mixture is poured into NaOH and the product is extracted using methylene chloride. After concentrating, the excess of amine is distilled off in vacuo and the residue is crystallized using hexane. 9.5 g=55%

Aufarbeitung

  1. temperatureAfter cooling
  2. extractionthe product is extracted
  3. concentrationAfter concentrating
  4. distillationthe excess of amine is distilled off in vacuo
  5. customthe residue is crystallized

Quellen und Nachweise

ORD-Eintrag
ord-ed5d30e63cae482aa9ed8a44a63361f9
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05723450

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