Sodium borohydride → 5-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-ol

HRID 1010798Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1010798
[OH:1][CH2:2][CH2:3][N:4]1[CH2:10][C:9](=[O:11])[C:6]2([CH2:8][CH2:7]2)[CH2:5]1.[BH4-].[Na+]>CO>[OH:1][CH2:2][CH2:3][N:4]1[CH2:10][CH:9]([OH:11])[C:6]2([CH2:7][CH2:8]2)[CH2:5]1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 167382835-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-one

Produkt 1

HCID 167382855-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

5-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-one (100 mg) was dissolved into Methanol (8 ml) and stirred at RT. NaBH4 (100 mg) was added to the reaction and stirred at RT for 30 minutes. The reaction was evaporated and purified by column chromatography to give title compound. Mass: (M+1), 158

Aufarbeitung

  1. stirringstirred at RT for 30 minutes
  2. customThe reaction was evaporated
  3. custompurified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-0effb4b5009a43d2a870d2f4eaaaca35
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977346B2

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