Triethylamine → HCID 22402475, Verbindung

HRID 1010992

Reaktionsgleichung

Reaktionsgleichung von HRID 1010992
[O:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][OH:8])[CH2:2]1.C(N(CC)CC)C.[S:16](Cl)([CH3:19])(=[O:18])=[O:17]>ClCCl>[CH3:19][S:16]([O:8][CH2:7][CH:3]1[CH2:4][CH2:5][CH2:6][O:1][CH2:2]1)(=[O:18])=[O:17]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 85769Tetrahydro-2H-pyran-3-methanol

Produkt 1

HCID 22402475HCID 22402475, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To tetrahydro-2H-pyran-3-ylmethanol (4.92 g) in dry dichloromethane (140 ml) at 0° C. and under nitrogen, was added anhydrous triethylamine (13.6 ml) in one go, followed by mesyl chloride (4.3 ml) dropwise over 5 minutes. The reaction was allowed to warm to room temperature and stirred at this temperature overnight. The reaction was quenched with saturated aqueous sodium bicarbonate (50 ml). The organic layer was separated, passed through a hydrophobic frit to dry and concentrated in vacuo to yield a red oil (8.8 g).

Aufarbeitung

  1. customThe reaction was quenched with saturated aqueous sodium bicarbonate (50 ml)
  2. customThe organic layer was separated
  3. customto dry
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-da1ea2a94585412492498f6165dd4248
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977344B2

Verknüpfte Notizen

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