4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine → 4-(4-tert-Butylcyclohexylamino)-3-methoxy-2-methylpyridine

HRID 1011

Reaktionsgleichung

Reaktionsgleichung von HRID 1011
[C:1]([C:5]1[CH:20]=[CH:19][C:8]([NH:9][C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH3:16])[C:11]=2[O:17][CH3:18])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>CO.Cl.O>[C:1]([CH:5]1[CH2:20][CH2:19][CH:8]([NH:9][C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH3:16])[C:11]=2[O:17][CH3:18])[CH2:7][CH2:6]1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

5

Edukt 1

HCID 196939534-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine

Produkt 1

HCID 544512624-(4-tert-Butylcyclohexylamino)-3-methoxy-2-methylpyridine

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

1 g of 4-(4-tert-butylanilino)-3-methoxy-2-methylpyridine in 20 ml of methanol, 3.7 ml of 2N HCl and 1.3 ml of water are hydrogenated at room temperature and normal pressure until absorption of hydrogen has ended using 1 g of rhodium on alumina (5% strength). After filtering and concentrating 1 g of syrup remains=100% isomer mixture.

Aufarbeitung

  1. customare hydrogenated at room temperature
  2. customnormal pressure until absorption of hydrogen
  3. filtrationAfter filtering
  4. concentrationconcentrating 1 g of syrup

Quellen und Nachweise

ORD-Eintrag
ord-61a0177588e440db829d21a8578b91c1
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05723450

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