Water → 2-Aminocarbonylamino-5-(4-bromophenyl)-4-chloropyrrole-3-carboxamide

HRID 1011577Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1011577
[Cl:1]N1C(=O)CCC1=O.[NH2:9][C:10]([NH:12][C:13]1[NH:14][C:15]([C:21]2[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=2)=[CH:16][C:17]=1[C:18]([NH2:20])=[O:19])=[O:11].O>CN(C)C=O>[NH2:9][C:10]([NH:12][C:13]1[NH:14][C:15]([C:21]2[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=2)=[C:16]([Cl:1])[C:17]=1[C:18]([NH2:20])=[O:19])=[O:11]

Komponenten

5

Edukt 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 250057042-Aminocarbonylamino-5-(4-bromophenyl)pyrrole-3-carboxamide

Produkt 1

HCID 592858832-Aminocarbonylamino-5-(4-bromophenyl)-4-chloropyrrole-3-carboxamideAusbeute 51 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

N-Chlorosuccinimide (48 mg, 0.36 mmol) was added to a solution of 2-aminocarbonylamino-5-(4-bromophenyl)pyrrole-3-carboxamide (Compound No. 1-1, 97 mg, 0.30 mmol) in anhydrous N,N-dimethylformamide (2 mL), and the mixture was stirred overnight at 50° C. After cooling, water (4 mL) was added thereto, the precipitated solid was filtered off, and washed with water (5 mL). The obtained solid was dried under reduced pressure to give the target compound (54 mg) as a pale brown solid (Yield 51%).

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationthe precipitated solid was filtered off
  3. washwashed with water (5 mL)
  4. customThe obtained solid was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4d0288762c754547860d5c69e09d62bf
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977371B2

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