2-Aminocarbonylamino-5-(4-vinylphenyl)pyrrole-3-carboxamide → 2-Aminocarbonylamino-5-(4-ethylphenyl)pyrrole-3-carboxamide

HRID 1011582Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1011582
[NH2:1][C:2]([NH:4][C:5]1[NH:6][C:7]([C:13]2[CH:18]=[CH:17][C:16]([CH:19]=[CH2:20])=[CH:15][CH:14]=2)=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])=[O:3]>[Pd].CO>[NH2:1][C:2]([NH:4][C:5]1[NH:6][C:7]([C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH3:20])=[CH:15][CH:14]=2)=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])=[O:3]

Komponenten

4

Edukt 1

HCID 250029182-Aminocarbonylamino-5-(4-vinylphenyl)pyrrole-3-carboxamide

Produkt 1

HCID 592858602-Aminocarbonylamino-5-(4-ethylphenyl)pyrrole-3-carboxamideAusbeute 62,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

10% Palladium on activated carbon (6 mg) was added to a solution of 2-aminocarbonylamino-5-(4-vinylphenyl)pyrrole-3-carboxamide (Compound No. 9-1, 16 mg, 0.059 mmol) in methanol (2 mL) and the mixture was stirred at room temperature for 4.5 hours under hydrogen gas atmosphere. After the reaction solution was filtered, the filterate was concentrated in vacuo. The obtained solid was washed with diethyl ether (2 mL) and dried under reduced pressure to give the target compound (10 mg) as a colorless solid (Yield 62%).

Aufarbeitung

  1. filtrationAfter the reaction solution was filtered
  2. concentrationthe filterate was concentrated in vacuo
  3. washThe obtained solid was washed with diethyl ether (2 mL)
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ec598e5e53524e5fa5571f59ffa87c96
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977371B2

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