Lactic Acid → Isonicotinic Acid Amide Lactic Acid

HRID 10119

Reaktionsgleichung

Reaktionsgleichung von HRID 10119
C1SC(NC(N)=N)=NC=1CSCCC(NS(N)(=O)=O)=N.[C:21]([NH2:29])(=[O:28])[C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1.[C:30]([OH:35])(=[O:34])[CH:31]([CH3:33])[OH:32]>O>[C:21]([NH2:29])(=[O:28])[C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1.[C:30]([OH:35])(=[O:34])[CH:31]([CH3:33])[OH:32]

Komponenten

5

Edukt 3

HCID 612Lactic AcidHCID 15074IsonicotinamideHCID 178418935HCID 178418935, Verbindung2×

Produkt 1

HCID 86591738Isonicotinic Acid Amide Lactic Acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

To 1 g of famotidine and 5 g of isonicotinic acid amide were added about 80 ml of water for injection and 2.20 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was added to make the total volume 100 ml, whereby an injection solution having a pH of 6.2 and a kinematic viscosity at room temperature of 0.95 centistokes was obtained.

Aufarbeitung

  1. dissolutionto dissolve them
  2. additionwas added
  3. customa kinematic viscosity at room temperature of 0.95 centistokes was obtained

Quellen und Nachweise

ORD-Eintrag
ord-6961669486c8494bb2c3a3bdd60048e7
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094414B2

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