HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethyl 2-acetylacetoacetate → ethyl 3,5-dimethyl-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazole-4-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethyl 2-acetylacetoacetate | HCID 79063 | — |
| Edukt | 4-(Trifluoromethoxy)phenylhydrazine hydrochloride | HCID 2777328 | — |
| Produkt | ethyl 3,5-dimethyl-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazole-4-carboxylate | HCID 23646848 | 72% |
Reaktionsschritte
In analogy to the procedure described in Example 38A], (4-trifluoromethoxy-phenyl)-hydrazine hydrochloride and ethyl diacetoacetate gave, after extraction (3× Et2O), drying (Na2SO4) and evaporation, the title compound in 72% yield as orange oil. MS: 328.9 (MH+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07977358B2 |
| Quelldatensatz | uspto-grants-2011_07 |
| ORD ID | ord-ba75282944304bf294184a7360c7e186 |
| Quellennotiz | uspto-grants-2011_07 |