Ethyl 2-aminobenzoate → Ethyl 2-(1H-pyrrol-1-yl)benzoate

HRID 1013145Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1013145
[CH2:1]([O:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH2:11])[CH3:2].CO[CH:15]1[CH2:19][CH2:18][CH:17](OC)O1>C(O)(=O)C>[CH2:1]([O:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH:15]=[CH:19][CH:18]=[CH:17]1)[CH3:2]

Komponenten

4

Edukt 2

HCID 6877Ethyl 2-aminobenzoateHCID 790982,5-Dimethoxytetrahydrofuran

Produkt 1

HCID 12673310Ethyl 2-(1H-pyrrol-1-yl)benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a stirred solution of 2-amino benzoic acid ethyl ester (20 g; 121 mmol) in acetic acid (35 mL) was added 2,5-dimethoxytetrahydrofuran (19 g; 174 mmol). The reaction mixture was stirred for two hours at reflux. After evaporation of the solvent, the crude product was purified by flash column chromatography (methylene chloride) to give compound 2-pyrrol-1-yl-benzoic acid ethyl ester as a yellow oil.

Aufarbeitung

  1. temperatureat reflux
  2. customAfter evaporation of the solvent
  3. customthe crude product was purified by flash column chromatography (methylene chloride)

Quellen und Nachweise

ORD-Eintrag
ord-13351d2d816642799b830ec75ccde29a
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07981907B2

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