Potassium Carbonate → 4,5,6,7,7a,8-Hexahydro-3bH-1-thia-5-aza-cyclopenta[alpha]indene

Temperatur

22 °C

The product from step g) (963 mg, 3.58 mmol) in dichloroethane (18 ml) was treated with K2CO3 (1.97 g, 14.3 mmol) and Ace-Cl (1.54 ml, 14.3 mmol) at 80° C. for 16 hours. Next, the reaction mixture was filtered, concentrated and the residue was dissolved in anhydrous MeOH (25 ml) and stirred for 1 h at 22° C. The MeOH was concentrated and triturated with ether to give 467 mg (61%) of the subtitle compound. MS calculated for C10H13NS+H 180, observed 180.

1. filtrationNext, the reaction mixture was filtered
2. concentrationconcentrated
3. dissolutionthe residue was dissolved in anhydrous MeOH (25 ml)
4. concentrationThe MeOH was concentrated
5. customtriturated with ether

ORD-Eintrag

ord-0c1ca1f974824793865d30153523bc10

Quelldatensatz

uspto-grants-2011_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07981919B2