(4,5,6,7-Tetrahydro-1H-indazol-4-yl)-carbamic acid benzyl ester → 4,5,6,7-tetrahydro-1H-indazol-4-amine

HRID 1013815Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1013815
C(OC(=O)[NH:10][CH:11]1[CH2:19][CH2:18][CH2:17][C:16]2[NH:15][N:14]=[CH:13][C:12]1=2)C1C=CC=CC=1>[Pd]>[NH:15]1[C:16]2[CH2:17][CH2:18][CH2:19][CH:11]([NH2:10])[C:12]=2[CH:13]=[N:14]1

Komponenten

3

Edukt 1

HCID 67316351(4,5,6,7-Tetrahydro-1H-indazol-4-yl)-carbamic acid benzyl ester

Produkt 1

HCID 219419414,5,6,7-tetrahydro-1H-indazol-4-amineAusbeute 96,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

Stir a mixture of (4,5,6,7-tetrahydro-1H-indazol-4-yl)-carbamic acid benzyl ester (3.5 g) methanol (50 mL) and palladium on carbon (10%, 0.7 g) on a hydrogenation parr shaker under 50 psi for 3 hours. Remove the reaction from parr shaker and filter the mixture through celite. Concentrate the filtrate to afford 1.7 g of the title compound.

Aufarbeitung

  1. customRemove
  2. customthe reaction from parr shaker
  3. filtrationfilter the mixture through celite
  4. concentrationConcentrate the filtrate

Quellen und Nachweise

ORD-Eintrag
ord-3b66fb58425a4c86b98687bcc6863b5d
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07981918B2

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