Dipropylamine → 3-(Dipropylcarbamoyl)benzoic acid

HRID 1014863

Reaktionsgleichung

Reaktionsgleichung von HRID 1014863
C(OC(N1C[C@H](O)C[C@@H]1C(O)=O)=O)(C)(C)C.[CH2:17]([N:20]([CH2:33][CH2:34][CH3:35])[C:21]([C:23]1[CH:24]=[C:25]([CH:30]=[CH:31][CH:32]=1)[C:26]([O:28]C)=[O:27])=[O:22])[CH2:18][CH3:19].COC(C1C=C(C=CC=1)C(O)=O)=O.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(NCCC)CC>CN(C=O)C.C(OCC)(=O)C>[CH2:33]([N:20]([CH2:17][CH2:18][CH3:19])[C:21]([C:23]1[CH:24]=[C:25]([CH:30]=[CH:31][CH:32]=1)[C:26]([OH:28])=[O:27])=[O:22])[CH2:34][CH3:35]

Komponenten

8

Edukt 5

HCID 8902DipropylamineHCID 182776Benzoic acid, 3-((dipropylamino)carbonyl)-, methyl esterHCID 6018803-(Methoxycarbonyl)benzoic acidHCID 688616N-Boc-cis-4-hydroxy-D-prolineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

Produkt 1

HCID 1827693-(Dipropylcarbamoyl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Step E (1): Methyl 3-(dipropylcarbamoyl)benzoate. To a solution of 3-(methoxycarbonyl)benzoic acid (6.7 g, 37.2 mmol) in DMF (60 mL) was added HATU (17.0 g, 44.7 mmol) and dipropylamine (9.4 g, 93 mmol) and the reaction mixture was stirred at rt overnight. Ethyl acetate (600 mL) was added and the mixture was washed with H2O, dried and concentrated to give the title compound was used in the next step without purification.

Aufarbeitung

  1. washthe mixture was washed with H2O
  2. customdried
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-0756099cc8204c859264f0923d623d67
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07981913B2

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