8-Methylquinoline-5-carboxylic acid → 8-Methyl-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

HRID 1017130Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1017130
[CH3:1][C:2]1[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1.[H][H]>[Pd].C(O)C>[CH3:1][C:2]1[C:11]2[NH:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 129507838-Methylquinoline-5-carboxylic acidHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 139517338-Methyl-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

0.1 mol of 8-methylquinoline-5-carboxylic acid was suspended in 1.5 1 of ethanol and admixed with 10.0 g of palladium on activated carbon (5%). In an autoclave, the mixture was reduced at 50° C. with hydrogen (1 bar) over a period of 48 hours (HPLC monitoring). The reaction mixture was subsequently filtered, the filter cake was washed with ethanol and the combined organic filtrates were concentrated.

Aufarbeitung

  1. filtrationThe reaction mixture was subsequently filtered
  2. washthe filter cake was washed with ethanol
  3. concentrationthe combined organic filtrates were concentrated

Quellen und Nachweise

ORD-Eintrag
ord-ff2acbc3e664438e90c8f8519055686b
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06479436B1

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