Acetic Acid → N-benzyl-6-chloro-4-o-tolyl-nicotinamide

HRID 1017483

Reaktionsgleichung

Reaktionsgleichung von HRID 1017483
[CH2:1]([NH:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[N:12][CH:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:18]1([CH3:26])[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[Mg]Cl.C(O)(=O)C>C1COCC1.O.O.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.[Mn+3]>[CH2:1]([NH:8][C:9](=[O:17])[C:10]1[C:15]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[CH3:26])=[CH:14][C:13]([Cl:16])=[N:12][CH:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

6

Edukt 3

HCID 176Acetic AcidHCID 857488N-Benzyl-6-chloro-nicotinamideHCID 178424304HCID 178424304, Verbindung

Produkt 1

HCID 12167314N-benzyl-6-chloro-4-o-tolyl-nicotinamideAusbeute 89,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 12416832Manganese triacetate dihydrateKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A solution of 0.5 g (2.0 mMol) N-benzyl-6-chloro-nicotinamide in 5.0 ml THF was added over 25 minutes to 10.1 ml (10.1 mMol) of o-tolylmagnesium chloride solution (1M in THF) cooled to 0° C. After 2.5 hours stirring at room temperature, the reaction mixture was cooled again to 0° C. and 4.0 ml acetic acid were added over 15 minutes followed by 1.1 g (4.1 mMol) manganese triacetate dihydrate. After stirring for 1 hour at room temperature, the reaction mixture was filtered and the filtrate was poured onto 20 ml deionized water. Sodium bicarbonate was added portionwise to bring the pH to 7 and the phases were separated. The aqueous layer was extracted with dichloromethane. The combined organic extracts were washed with water, dried (Na2SO4) and evaporated. The residue was purified by flash chromatography (eluent ethyl acetate/n-hexane 2:1) to yield 0.6 g (88%) N-benzyl-6-chloro-4-o-tolyl-nicotinamide as an orange resin.

Aufarbeitung

  1. temperaturethe reaction mixture was cooled again to 0° C.
  2. stirringAfter stirring for 1 hour at room temperature
  3. filtrationthe reaction mixture was filtered
  4. additionthe filtrate was poured onto 20 ml
  5. additionSodium bicarbonate was added portionwise
  6. customthe phases were separated
  7. extractionThe aqueous layer was extracted with dichloromethane
  8. washThe combined organic extracts were washed with water
  9. dry with materialdried (Na2SO4)
  10. customevaporated
  11. customThe residue was purified by flash chromatography (eluent ethyl acetate/n-hexane 2:1)

Quellen und Nachweise

ORD-Eintrag
ord-ab7aa32dba7844d487ca5ef05bcd4f72
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06479483B2

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