HCID 178418361, Verbindung → HCID 178486573, Verbindung

HRID 1017749

Reaktionsgleichung

Reaktionsgleichung von HRID 1017749
[NH:1]1[CH:5]=[C:4]([CH:6]2[C:14]3[C:9](=[C:10]([CH3:18])[C:11]([CH3:17])=[C:12]([O:15][CH3:16])[CH:13]=3)[CH:8](O)[CH2:7]2)[N:3]=[CH:2]1.[H][H]>C(O)C.Cl.[Pd]>[CH3:16][O:15][C:12]1[CH:13]=[C:14]2[C:9]([CH2:8][CH2:7][CH:6]2[C:4]2[N:3]=[CH:2][NH:1][CH:5]=2)=[C:10]([CH3:18])[C:11]=1[CH3:17]

Komponenten

6

Edukt 2

HCID 178418361HCID 178418361, VerbindungHCID 178486576HCID 178486576, Verbindung

Produkt 1

HCID 178486573HCID 178486573, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 313Hydrochloric AcidLösungsmittelHCID 702EthanolLösungsmittel

Versuchsvorschrift

3-(1H-Imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-ol (0.29 g) is dissolved in the mixture of ethanol (30 ml) and concentrated hydrochloric acid (0.2 ml). The solution is hydrogenated at 50-55° C. with 10% palladium on carbon as catalyst until no more hydrogen is consumed. The mixture is filtered and the filtrate is evaporated to dryness. The residue is crystallized from the mixture of ethyl acetate and ethanol. M.p. of the hydrochloride salt is 174-177° C.

Aufarbeitung

  1. customis consumed
  2. filtrationThe mixture is filtered
  3. customthe filtrate is evaporated to dryness
  4. customThe residue is crystallized from the mixture of ethyl acetate and ethanol
  5. customis 174-177° C.

Quellen und Nachweise

ORD-Eintrag
ord-0c3feb80b17743559748952c902e3985
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06479530B2

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