S(=O)(=O)(O)O.Cl.[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]([CH2:19][C:20]1[N:21]=[CH:22][NH:23][CH:24]=1)[CH2:14][CH2:13][CH2:12]2.[C:25](O)([CH3:28])([CH3:27])[CH3:26].[OH-].[Na+]>O>[C:25]([C:18]1[CH:17]=[C:16]2[C:11]([CH2:12][CH2:13][CH2:14][CH:15]2[CH2:19][C:20]2[N:21]=[CH:22][NH:23][CH:24]=2)=[CH:10][C:9]=1[O:8][CH3:7])([CH3:28])([CH3:27])[CH3:26]Sulfuric acid (0.75 ml) is added into the mixture of 4-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-1H-imidazole hydrochloride (75 mg) and tert-butanol (3 ml). The mixture is stirred at 35-40° C. for 15 hours. The reaction mixture is poured into water and is made alkaline with sodium hydroxide. The product is extracted into methylene chloride which is washed with water, dried with sodium sulfate and evaporated to dryness. The residue consisting of crude product is coverted to its hydrochloride salt in ethyl acetate. The yield is 40 mg.
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