Pyridine → 4-Oxo-undecanoyl Chloride

HRID 1018159

Reaktionsgleichung

Reaktionsgleichung von HRID 1018159
[O:1]=[C:2]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH2:3][CH2:4][C:5](O)=[O:6].N1C=CC=CC=1.S(Cl)([Cl:23])=O>CCOCC>[O:1]=[C:2]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH2:3][CH2:4][C:5]([Cl:23])=[O:6]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 52829854-Oxoundecanoic acid

Produkt 1

HCID 229905004-Oxo-undecanoyl Chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

To a suspension of 50 g 4-oxo-undecanoic acid (Synthesis, 1987, 408) in 350 ml of ether, 22.15 g pyridine was added in at 0° C. Then a solution of 32.72 g thionyl chloride in 50 ml of ether was added in at 0-5° C. and then the reaction mixture was stirred for 20 hours at room temperature. Then the reaction mixture was filtered and evaporated to dryness. The residue (53.83 g yellow oil) was not further purified.

Aufarbeitung

  1. additionwas added in at 0° C
  2. filtrationThen the reaction mixture was filtered
  3. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-98508d6c7eda41d6817d6ff96e3bd20f
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06479682B1

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