Ammonium Hydroxide → (S)-5-Hydroxytryptophan amide

Reaktionsgleichung

Cl.CO[C:4](=[O:18])[C@H:5]([CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[NH:10][CH:9]=1)[NH2:6].[OH-].[NH4+:20]>>[OH:17][C:14]1[CH:15]=[C:16]2[C:11]([NH:10][CH:9]=[C:8]2[CH2:7][C@@H:5]([C:4]([NH2:20])=[O:18])[NH2:6])=[CH:12][CH:13]=1

Komponenten

Edukt 2

HCID 14923Ammonium Hydroxide

HCID 24802218methyl (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoate hydrochloride

Produkt 1

HCID 9899303(S)-5-Hydroxytryptophan amide

Versuchsvorschrift

(S)-5-Hydroxytryptophan methyl ester hydrochloride (0.247 g, 0.91 mmol) was stirred overnight at room temperature in ammonium hydroxide (10 mL). After removal of volatiles under vacuum, the title compound of example 44 was obtained as a dark solid.

Aufarbeitung

customAfter removal of volatiles under vacuum

Quellen und Nachweise

ORD-Eintrag: ord-a6638a3dc1e34de09f15bc33e5dd0439
Quelldatensatz: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06479508B1

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