Hydrochloric Acid → HCID 18401893, Verbindung

HRID 1018662Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1018662
[CH:1]1([CH2:7][O:8][C:9]2[CH:10]=[CH:11][C:12]3[C:18](=[O:19])[CH2:17][CH2:16][CH2:15][CH2:14][C:13]=3[CH:20]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[BH4-].[Na+].Cl>CCO>[CH:1]1([CH2:7][O:8][C:9]2[CH:10]=[CH:11][C:12]3[CH:18]([OH:19])[CH2:17][CH2:16][CH2:15][CH2:14][C:13]=3[CH:20]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 10707356HCID 10707356, Verbindung

Produkt 1

HCID 18401893HCID 18401893, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To a suspension of 2-cyclohexylmethoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one (14.5 g, 53.23 mmol) in EtOH (150 mL) was added NaBH4 (1.96 g, 53.23 mmol) portionwise over 10 min. The mixture was heated to 40° C. for 1 h, cooled to 0° C., then made acidic with the addition of 1 N HCl. The white precipated solids were filtered, washed with water, and dried in vacuuo (14.25 g, 97%). m.p. 102-103° C.

Aufarbeitung

  1. temperaturecooled to 0° C.
  2. filtrationThe white precipated solids were filtered
  3. washwashed with water
  4. customdried in vacuuo (14.25 g, 97%)

Quellen und Nachweise

ORD-Eintrag
ord-314d397d5877494c97ff8a4b6e610389
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06482852B2

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