Ethylamine → 6-(Ethylamino)pyridine-3-carboxylic acid
Reaktionsgleichung
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12]>>[CH2:11]([NH:13][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1)[CH3:12]Komponenten
3
Versuchsvorschrift
This intermediate is prepared from 6-chloronicotinic acid and ethylamine by the same procedure as described for Example 35 step a). 1-Butanol was substituted for ethyl acetate for the extraction. Recrystallization (MeOH—CHCl3) yielded 0.53 g (50%).
Aufarbeitung
- extraction1-Butanol was substituted for ethyl acetate for the extraction
- customRecrystallization (MeOH—CHCl3)
- customyielded 0.53 g (50%)
Quellen und Nachweise
- ORD-Eintrag
- ord-263f43617b4f4ca7b9c9c14a546a1f8a
- Quelldatensatz
- uspto-grants-2002_11
- Patentnummer
- US06486183B1
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