2-(Azetidin-1-yl)-5-nitropyridine → 6-(Azetidin-1-yl)pyridin-3-amine

HRID 1019570Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1019570
[N:1]1([C:5]2[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][N:6]=2)[CH2:4][CH2:3][CH2:2]1.[H][H]>C(O)C.[Pd]>[NH2:11][C:8]1[CH:7]=[N:6][C:5]([N:1]2[CH2:4][CH2:3][CH2:2]2)=[CH:10][CH:9]=1

Komponenten

5

Edukt 2

HCID 668504742-(Azetidin-1-yl)-5-nitropyridineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 552816836-(Azetidin-1-yl)pyridin-3-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of 11.5 g (64.18 mmol) of 2-(azetidin-1-yl)-5-nitropyridine, prepared in the preceding stage, and 1 g of Pd/C at 10% in 400 mL of ethanol is stirred vigorously at 20° C. under 5 atm of hydrogen for 4 hours. After this time, the mixture is filtered on a Celite pad and then concentrated at reduced pressure. We thus obtain 9.3 g of the expected product, which is used as it is in the rest of the synthesis.

Aufarbeitung

  1. filtrationAfter this time, the mixture is filtered on a Celite pad
  2. concentrationconcentrated at reduced pressure
  3. customis in the rest of the synthesis

Quellen und Nachweise

ORD-Eintrag
ord-0d8a68cf0e2b47ac8625d4151a7a1763
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08716273B2

Notizen zur Reaktion

Wird geladen…