Sodium Iodide → HCID 58055059, Verbindung

HRID 1020252Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1020252
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15]Cl)[N:14]=1)=[O:8].[Na+].[I-:22]>CC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][I:22])[N:14]=1)=[O:8]

Komponenten

4

Edukt 2

HCID 5238Sodium IodideHCID 58055096HCID 58055096, Verbindung

Produkt 1

HCID 58055059HCID 58055059, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a solution of 1-(3,4-dichlorobenzyl)-3-(4-(chloromethyl)thiazol-2-yl)urea (1 eq) in acetone was added NaI (10 eq) at once. The mixture was stirred at room temperature for 2 h. The volatiles were removed in vacuo and the mixture was taken up in water and EtOAc. The layers were separated and the organic phase was partitioned with water and then brine, dried over Na2SO4, filtered, and concentrated in vacuo to afford 1-(3,4-dichlorobenzyl)-3-(4-(iodomethyl)thiazol-2-yl)urea as a tan-colored solid in near quantitative yield.

Aufarbeitung

  1. customThe volatiles were removed in vacuo
  2. customThe layers were separated
  3. customthe organic phase was partitioned with water
  4. dry with materialbrine, dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8c1b86b5c80a4221ad823633a1a6d3f4
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08716320B2

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