Methanol → 4-Methoxy-1H-pyrrolo[2,3-b]pyridine

HRID 1020905Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1020905
[OH-:1].[Na+].Cl[C:4]1[CH:12]=[CH:11][N:10]=[C:9]2[C:5]=1[CH:6]=[CH:7][NH:8]2.[CH3:13]O>>[CH3:13][O:1][C:4]1[CH:12]=[CH:11][N:10]=[C:9]2[C:5]=1[CH:6]=[CH:7][NH:8]2

Komponenten

4

Edukt 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 113894934-Chloro-1H-pyrrolo[2,3-b]pyridine

Produkt 1

HCID 112405674-Methoxy-1H-pyrrolo[2,3-b]pyridine

Versuchsvorschrift

A solution of sodium hydroxide (11 g) in methanol (250 mL) was stirred with 4-chloro-1H-pyrrolo[2,3-b]pyridine (step 2)(12.2 g, 80 mmol) at 140° C. in a sealed reactor for 16 hr. After being cooled to ambient temperature the mixture was concentrated and residue was slurred in water (100 mL) for one hour. The solid was collected by suction filtration and washed to neutrality with water. After being dried to constant weight, 6.5 g of 4-methoxy-7-azaindole was obtained as a tan solid; MS (m/z) 149 (M+H).

Aufarbeitung

  1. concentrationwas concentrated
  2. filtrationThe solid was collected by suction filtration
  3. washwashed
  4. customAfter being dried to constant weight

Quellen und Nachweise

ORD-Eintrag
ord-6d758ae00c394184803892307e5fcb4f
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08716493B2

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