Trifluoroacetic acid → 4-(Azetidin-3-yloxy)pyridine
Reaktionsgleichung
[N:1]1[CH:6]=[CH:5][C:4]([O:7][CH:8]2[CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)=[CH:3][CH:2]=1.C(O)(C(F)(F)F)=O>ClCCCl>[NH:10]1[CH2:11][CH:8]([O:7][C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[CH2:9]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
tert-Butyl 3-(pyridin-4-yloxy)azetidine-1-carboxylate (494 mg) was mixed with DCE (5 ml), and TFA (2 ml) was added thereto, followed by stirring at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure, and the obtained residue was purified by basic silica gel column chromatography (CHCl3/MeOH) to obtain 4-(azetidin-3-yloxy)pyridine (268 mg).
Aufarbeitung
- additionwas added
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe obtained residue was purified by basic silica gel column chromatography (CHCl3/MeOH)
Quellen und Nachweise
- ORD-Eintrag
- ord-4c367d2dd6f548c68e8a3513666a6c6d
- Quelldatensatz
- uspto-grants-2014_05
- Patentnummer
- US08716470B2
Notizen zur Reaktion
Wird geladen…