Water → 1,2-Dimethyl-4-nitro-1H-imidazole

HRID 1022255Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1022255
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=1.[C:10]([O-])([O-])=O.[K+].[K+].CI.O>CN(C=O)C>[CH3:10][N:3]1[CH:4]=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=[C:2]1[CH3:1]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178433402HCID 178433402, Verbindung

Produkt 1

HCID 257911,2-Dimethyl-4-nitro-1H-imidazoleAusbeute 45 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a mixture of 2-methyl-4-nitro-1H-imidazole (10.0 g, 78.7 mmol) and K2CO3 (21.7 g, 160 mmol) in DMF (80 mL) was added CH3I (13.4 g, 94 mmol) dropwise while stirring at room temperature. The mixture was stirred for 2 h. Water (200 mL) was then added to the mixture. The resulting suspension was filtered, washed with water, and dried in vacuo to afford 337a as a white solid (5.0 g, 45%). MS-ESI: [M+H]+ 142.1.

Aufarbeitung

  1. stirringThe mixture was stirred for 2 h
  2. filtrationThe resulting suspension was filtered
  3. washwashed with water
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-bcb264708d1944c0b0b10beb1a50e837
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08716274B2

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