Hydrochloric Acid → 2-(2-Pyridyloxy)acetic acid hydrochloride

HRID 1022732

Reaktionsgleichung

Reaktionsgleichung von HRID 1022732
C([O:5][C:6](=[O:15])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)(C)(C)C.[ClH:16]>C1COCC1>[ClH:16].[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][C:6]([OH:15])=[O:5]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 46168743Tert-butyl(pyridin-2-yloxy)acetate

Produkt 1

HCID 669759892-(2-Pyridyloxy)acetic acid hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl(pyridin-2-yloxy)acetate (0.18 g) in THF (1.5 mL) was added 6 mol/L hydrochloric acid (1.5 mL) at 0° C., and the mixture was warmed to room temperature, and stirred for 2 hr. The solvent was evaporated under reduced pressure, and the resultant solid was recrystallized from ethyl acetate and diisopropyl ether to give the title compound (0.11 g).

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. customthe resultant solid was recrystallized from ethyl acetate and diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-f42aa198ffd049f88bb95d785cff233c
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08722662B2

Verknüpfte Notizen

Wird geladen…