4-Chlorobutyryl chloride → HCID 66976296, Verbindung
Reaktionsgleichung
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([F:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.Cl[CH2:26][CH2:27][CH2:28][C:29](Cl)=[O:30]>>[ClH:16].[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][N:1]2[CH2:26][CH2:27][CH2:28][C:29]2=[O:30])=[CH:11][C:12]=1[F:17]Komponenten
3
Versuchsvorschrift
Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 4-chlorobutanoyl chloride, and by a method similar to that of Example 363, steps A and B and Example 39, step B, the title compound was obtained.
Quellen und Nachweise
- ORD-Eintrag
- ord-d32e85bcd6dc4ade86d8102f016f4576
- Quelldatensatz
- uspto-grants-2014_05