Sodium Hydroxide → 6-(Piperidin-4-yloxy)-isoquinolin-5-ylamine

HRID 1022870Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1022870
[OH-].[Na+].[NH:3]1CCC[C@H]1C(O)=O.[N-]=[N+]=[N-].[Na+].C(OC([N:22]1[CH2:27][CH2:26][CH:25]([O:28][C:29]2[C:30](Br)=[C:31]3[C:36](=[CH:37][CH:38]=2)[CH:35]=[N:34][CH:33]=[CH:32]3)[CH2:24][CH2:23]1)=O)(C)(C)C>C(O)C.O.[Cu]I.C(OCC)(=O)C.O>[NH:22]1[CH2:27][CH2:26][CH:25]([O:28][C:29]2[C:30]([NH2:3])=[C:31]3[C:36](=[CH:37][CH:38]=2)[CH:35]=[N:34][CH:33]=[CH:32]3)[CH2:24][CH2:23]1

Komponenten

9

Edukt 4

HCID 14798Sodium HydroxideHCID 33557Sodium AzideHCID 145742L-ProlineHCID 576469744-(5-Bromo-isoquinolin-6-yloxy)-piperidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 576469576-(Piperidin-4-yloxy)-isoquinolin-5-ylamineAusbeute 123,4 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)KatalysatorHCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittelHCID 19096565Water ethanolLösungsmittel

Reaktionsbedingungen

Temperatur
95 °C

Versuchsvorschrift

60 μL of 1N NaOH-solution, 6.9 mg (0.3 eq) of L-proline, 3.8 mg (0.1 eq) of CuI and 26 mg (0.4 mmol) of NaN3 were added to a solution of 82 mg (0.2 mmol) of 4-(5-Bromo-isoquinolin-6-yloxy)-piperidine-1-carboxylic acid tert-butyl ester (11) in 2 mL of ethanol/water (7/3). The mixture was heated to 95° C. for 3 h in a microwave reactor (CEM Discover). After cooling water and ethyl acetate were added and the mixture was filtered through a celite cartridge. After removal of the solvents by distillation the remainder was subjected to preparative HPLC. The N-Boc-protected intermediate was deprotected by treatment with 2 mL 5-6 N HCl in isopropanol for 2 h at room temperature. Then water was added and all solvents were removed by freeze drying to yield 18 mg of compound 31 as hydrochloride.

Aufarbeitung

  1. additionwere added
  2. filtrationthe mixture was filtered through a celite cartridge
  3. customAfter removal of the solvents
  4. distillationby distillation the remainder
  5. additionThen water was added
  6. customall solvents were removed by freeze
  7. customdrying

Quellen und Nachweise

ORD-Eintrag
ord-190a308d5817435b9cc730dd6f9102a1
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08722671B2

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