4-Methyl-3-nitroanisole → 5-Methoxy-o-toluidine

HRID 1023511

Reaktionsgleichung

Reaktionsgleichung von HRID 1023511
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[N+:10]([O-])=O>CO.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[NH2:10]

Komponenten

4

Edukt 1

HCID 871374-Methyl-3-nitroanisole

Produkt 1

HCID 995005-Methoxy-o-toluidineAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 1-methyl-4-(methyloxy)-2-nitrobenzene (20.0 g, 119.8 mmol) and Pd/C (10%, 3 g) in methanol (100 mL) was stirred under H2 atmosphere at room temperature overnight. The mixture was filtered through a pad of celite and the filtrate was evaporated under vacuum to afford the title compound as a solid (16.1 g).

Aufarbeitung

  1. filtrationThe mixture was filtered through a pad of celite
  2. customthe filtrate was evaporated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-d01c108b48d34b59a711ff7ccbd095f8
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08722695B2

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